Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme that contributes to the inflammation of blood vessels and the formation of plaque in the coronary arteries, increasing the risk of cardiovascular disease. As Lp-PLA2 is produced within the plaque, it is considered to be a more sensitive marker for assessing cardiovascular disease risk compared to traditional inflammatory markers like CRP. Therefore, measuring Lp-PLA2 levels in the blood can help identify individuals who are at higher risk of developing cardiovascular disease.